A new synthetic ultrasound-assisted method for dibenzoepines

In this study, we have developed a new ultrasonic synthesis method of dibenzoepines using olanzapine and quetiapine, which are well-known drugs for the treatment schizophrenia bipolar disorder. The is based on N-alkylation reaction piperazine fragment in tricyclic compounds with methyl iodide or 2-(2-chloroethoxy)ethanol as alkylating agent, respectively. reactions were carried out an bath solvents such acetonitrile dimethylformamide presence potassium sodium carbonate hydroxide metal-free, ecological phase transfer catalyst at temperature 40–50 °C. This allowed us to obtain 1 h (Y = 67%), quetiapine 3 72%). An reactor (Qsonica Q700) was used made it possible shorten time 10 min 90% yield very high purity. allows obtaining mild conditions short time, thanks process more than others described literature.